Glucovance 1000Mg/5Mg Tabs30'S

Glucovance 1000 mg/5 mg Tablets (30's)

✅ Active Ingredients:

• Glyburide (Glibenclamide) 5 mg (Sulfonylurea class)
• Metformin Hydrochloride 1000 mg (Biguanide class)

✅ Therapeutic Class:

• Antidiabetic agent (Combination of sulfonylurea and biguanide)

✅ Indication:

• Used to manage type 2 diabetes mellitus in adults.
• Helps control blood sugar levels when diet and exercise alone are insufficient.
• Metformin reduces glucose production in the liver and improves insulin sensitivity.
• Glyburide stimulates the pancreas to release more insulin.

✅ Mechanism of Action:

1. Glyburide (Sulfonylurea):

   • Stimulates the pancreatic beta cells to release more insulin, helping to lower blood glucose levels.
   • Reduces glucose production in the liver.

2. Metformin (Biguanide):

   • Reduces hepatic glucose production.
   • Increases insulin sensitivity in peripheral tissues, making the body use insulin more effectively.
   • Slows down intestinal glucose absorption.

✅ Dosage & Administration:

• Taken once or twice daily, with meals, to reduce the risk of gastrointestinal side effects.
• Tablets must be swallowed whole; do not crush, split, or chew.
• The dose is individualized based on blood glucose levels and tolerance.

✅ Contraindications:

• Severe renal impairment (eGFR < 30 mL/min/1.73m²)
• Metabolic acidosis (including diabetic ketoacidosis)
• Hypersensitivity to glyburide, metformin, or any excipients
• Pregnancy and breastfeeding (unless prescribed by a doctor)

✅ Warnings & Precautions:

• Regular monitoring of renal function is essential, especially during the initiation of treatment.
• Risk of lactic acidosis in cases of renal or hepatic impairment.
• May cause hypoglycemia (especially with glyburide), so monitor blood sugar closely, particularly when combined with other hypoglycemic agents.
• Alcohol consumption should be minimized, as it increases the risk of lactic acidosis and hypoglycemia.

✅ Common Side Effects:

• Gastrointestinal issues (nausea, diarrhea, abdominal discomfort)
• Hypoglycemia (low blood sugar)
• Dizziness or lightheadedness
• Headache
• Fatigue
• Skin reactions (rash or itching)

✅ Storage Conditions:

• Store at room temperature (15-30°C).
• Keep in a dry place, away from direct sunlight.
• Keep out of reach of children.

✅ Manufacturer:

• Merck 

✅ Country of Manufacture:

• Spain