Synjardy 5/850 Mg F/C Tabs 60'S

Synjardy 5 mg/850 mg Film-Coated Tablets (60's)

✅ Active Ingredients:

• Empagliflozin 5 mg (SGLT2 inhibitor)
• Metformin Hydrochloride 850 mg (Biguanide class)

✅ Therapeutic Class:

• Antidiabetic agent (Combination of SGLT2 inhibitor and biguanide)

✅ Indication:

• Used for the management of type 2 diabetes mellitus in adults.
• Helps improve glycemic control when diet and exercise alone are insufficient.
• Lowers blood sugar by blocking glucose reabsorption in the kidneys and reducing glucose production in the liver.
• Provides additional benefits such as weight management and cardiovascular protection in patients at risk.

✅ Mechanism of Action:

1. Empagliflozin (SGLT2 inhibitor):

   • Inhibits sodium-glucose cotransporter-2 (SGLT2) in the kidneys.
   • Increases urinary glucose excretion, leading to lower blood sugar levels.
   • Reduces glucose toxicity and insulin resistance.

2. Metformin (Biguanide):

   • Reduces hepatic glucose production.
   • Improves insulin sensitivity in peripheral tissues.
   • Slows down intestinal glucose absorption.

✅ Dosage & Administration:

• Taken once or twice daily with meals to minimize gastrointestinal discomfort.
• Tablets must be swallowed whole; do not crush, split, or chew.
• Dose adjustments may be required based on renal function and patient tolerance.

✅ Contraindications:

• Severe renal impairment (eGFR < 30 mL/min/1.73m²)
• Metabolic acidosis (including diabetic ketoacidosis)
• Hypersensitivity to empagliflozin, metformin, or any excipients

✅ Warnings & Precautions:

• Kidney function should be assessed before and during treatment.
• Risk of lactic acidosis, especially in renal or hepatic impairment.
• May cause hypotension due to fluid loss, particularly in elderly patients or those on diuretics.
• Increased risk of genital and urinary tract infections due to glucosuria.
• Should be avoided during pregnancy and breastfeeding, unless prescribed by a doctor.

✅ Common Side Effects:

• Gastrointestinal discomfort (nausea, diarrhea, abdominal pain)
• Increased urination (polyuria)
• Mild dehydration or dizziness
• Genital infections (e.g., yeast infections, balanitis)
• Low blood sugar (hypoglycemia) when combined with insulin or sulfonylureas

✅ Storage Conditions:

• Store at room temperature (15-30°C).
• Keep in a dry place, away from direct sunlight.
• Keep out of reach of children.

✅ Manufacturer:

• Boehringer Ingelheim (Germany)

✅ Country of Manufacture:

• Germany